Anti-CD8A Mouse Monoclonal Antibody (FITC (Fluorescein)) [clone: OKT8]

Supplier: Tonbo Biosciences
35-0086-T500EA 454 EUR
35-0086-T500 35-0086-T025 35-0086-T100
Anti-CD8A Mouse Monoclonal Antibody (FITC (Fluorescein)) [clone: OKT8]
Antibodies
The OKT8 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

The OKT8 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. If used together with alternative antibodies Anti-Human CD8a clone RPA-T8 or Anti-Human CD8a clone Hit8a, the OKT8 antibody will not block binding of RPA-T8 or Hit8a.

Type: Primary
Antigen: CD8A (CD8a molecule)
Clonality: monoclonal
Clone: OKT8
Conjugation: FITC (Fluorescein)
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human
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