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Anti-CRYAB Mouse Monoclonal Antibody [clone: 1D11C6E6]

Supplier: Thermo Scientific
MA5-15383 targets CRYAB in IHC and WB applications and shows reactivity with Human samples. The MA5-15383 immunogen is purified recombinant fragment of CRYAB (aa1-175) expressed in E. Coli. Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products--alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition.  In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation.  It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander’s disease where it accumulates in brain cells of those afflicted.

Type: Primary
Antigen: CRYAB
Clonality: Monoclonal
Clone: 1D11C6E6
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAMA515383 Blocked
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SPECIFICATIONS

Antigen symbol CRYAB
Antigen name Crystallin Alpha B
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 1D11C6E6
Host Mouse
Isotype IgG2a
Western Blot Yes
ImmunoChemistry Yes
Antigen synonyms CTPP2, CRYA2, CRYAB, HSPB5
Gene ID 1410
Format ascites
Immunogen Purified recombinant fragment of CRYAB (aa1-175) expressed in E. Coli.
Form Liquid
Storage Buffer ascites, 0.03% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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