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Anti-GATA3 Mouse Monoclonal Antibody [clone: 1A10D1]

Supplier: Thermo Scientific
MA5-15387 targets GATA3 in WB applications and shows reactivity with Human samples. The MA5-15387 immunogen is purified recombinant fragment of GATA3 (aa175-388) expressed in E. Coli. GATA3: GATA binding protein 3. The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1,but no other structural homologies between the 2 genes could be found.

Type: Primary
Antigen: GATA3
Clonality: Monoclonal
Clone: 1A10D1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAMA515387 Blocked
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SPECIFICATIONS

Antigen symbol GATA3
Antigen name GATA binding Protein 3
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 1A10D1
Host Mouse
Isotype IgG1
Western Blot Yes
Antigen synonyms HDR, MGC5445, GATA3, MGC5199, MGC2346
Gene ID 2625
Format ascites
Immunogen Purified recombinant fragment of GATA3 (aa175-388) expressed in E. Coli.
Form Liquid
Storage Buffer ascites, 0.03% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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