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Anti-ESR1 Mouse Monoclonal Antibody [clone: 10H12B10]

Supplier: Thermo Scientific
MA5-15402 targets ESR1 in WB applications and shows reactivity with Human samples. The MA5-15402 immunogen is purified recombinant fragment of ESR1 (aa301-595) expressed in E. Coli. <br>. ESR1: estrogen receptor 1. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Type: Primary
Antigen: ESR1
Clonality: Monoclonal
Clone: 10H12B10
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAMA515402 Blocked
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SPECIFICATIONS

Antigen symbol ESR1
Antigen name Estrogen Receptor 1
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 10H12B10
Host Mouse
Isotype IgG1
Western Blot Yes
Antigen synonyms DKFZp686N23123, NR3A1, ESR, ESRA, ESR1, Era, ER
Gene ID 2099
Format ascites
Immunogen Purified recombinant fragment of ESR1 (aa301-595) expressed in E. Coli.
Form Liquid
Storage Buffer ascites, 0.03% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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