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Anti-JNK3 Mouse Monoclonal Antibody [clone: 10E4A4]

Supplier: Thermo Scientific
MA5-15403 targets MAPK10 in IF and WB applications and shows reactivity with Human and mouse samples. The MA5-15403 immunogen is purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli. MA5-15403 detects MAPK10 which has a predicted molecular weight of approximately 53kDa. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases . Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 . Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Type: Primary
Antigen: JNK3
Clonality: Monoclonal
Clone: 10E4A4
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAMA515403 Blocked
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SPECIFICATIONS

Antigen symbol JNK3
Antigen name c-Jun N-terminal kinase 3
Reactivity Human, Mouse
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 10E4A4
Host Mouse
Isotype IgG1
Western Blot Yes
ImmunoFluorescence Yes
Antigen synonyms p54bSAPK, JNK3A, PRKM10, MAPK10, JNK3
Gene ID 5602, 26414
Format ascites
Immunogen Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.
Form Liquid
Storage Buffer ascites, 0.03% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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