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Anti-HER2 Mouse Monoclonal Antibody [clone: 6C2B12,9B9D8]

Supplier: Thermo Scientific
MA5-15405 targets ERBB2 in IHC and WB applications and shows reactivity with Human samples. The MA5-15405 immunogen is purified recombinant fragment of human ERBB2 (aa750-987) expressed in E. Coli.<br>. This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Type: Primary
Antigen: HER2
Clonality: Monoclonal
Clone: 6C2B12,9B9D8
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1/IgG2b
Reactivity: Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAMA515405 Blocked
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Antigen symbol HER2
Antigen name Receptor tyrosine-protein kinase erbB-2
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 6C2B12,9B9D8
Host Mouse
Isotype IgG1/IgG2b
Western blot Yes
ImmunoChemistry Yes
Antigen synonyms NEU, MLN 19, p185erbB2, CD340, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, c-erb B2/neu protein, herstatin, MLN19, NGL, Proto-oncogene c-ErbB-2, metas, Tyrosine kinase-type cell surface receptor HER2
Gene ID 2064
Format ascites
Immunogen Purified recombinant fragment of human ERBB2 (aa750-987) expressed in E. Coli.
Form Liquid
Storage buffer ascites, 0.03% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping temperature Ice
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