Keep my session open?
Ending In 
The session is expired
Your session has expired. For your security, we have logged you out.
Would you like to log in again?

Anti-HER2 Mouse Monoclonal Antibody [clone: 6C2B12,9B9D8]

Supplier: Thermo Scientific
MA5-15405 targets ERBB2 in IHC and WB applications and shows reactivity with Human samples. The MA5-15405 immunogen is purified recombinant fragment of human ERBB2 (aa750-987) expressed in E. Coli.<br>. This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Type: Primary
Antigen: HER2
Clonality: Monoclonal
Clone: 6C2B12,9B9D8
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1/IgG2b
Reactivity: Human



Log in to see your contract pricing and availability.
  Remember me on this device
 

ORDER

Expand All / Collapse All
Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAMA515405 Blocked
Blocked This product has been blocked by your organisation. Please contact your purchasing department for more information.
Generate Barcodes Barcode Label Format: 
Generate PDF Catalog Page

SPECIFICATIONS

Antigen symbol HER2
Antigen name Receptor tyrosine-protein kinase erbB-2
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 6C2B12,9B9D8
Host Mouse
Isotype IgG1/IgG2b
Western Blot Yes
ImmunoChemistry Yes
Antigen synonyms NEU, MLN 19, p185erbB2, CD340, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, c-erb B2/neu protein, herstatin, MLN19, NGL, Proto-oncogene c-ErbB-2, metas, Tyrosine kinase-type cell surface receptor HER2
Gene ID 2064
Format ascites
Immunogen Purified recombinant fragment of human ERBB2 (aa750-987) expressed in E. Coli.
Form Liquid
Storage Buffer ascites, 0.03% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
Enter Details

Select the article for which you are looking for Certificate

Indicate the Lot Number. This field is mandatory. Enter 'x' if unknown for VWR Chemicals

Enter Certificate Details

Select Product:

Enter the Lot number:

Choose from recent batch/lot numbers:

Or
Review & Compare Alternatives
We found alternative products that can save you up to  per item-unit.  To compare product details, select up to 3 alternatives below and click Compare Selected. To add items to your basket, enter a quantity and click Add to Basket.

Original Product:

Description Catalog Number Availability Unit Your Price Price Per Qty