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Anti-PYK2 Mouse Monoclonal Antibody [clone: 5E2D5]

Supplier: Thermo Scientific
MA5-15407 targets PYK2 in IHC and WB applications and shows reactivity with Human samples. The MA5-15407 immunogen is purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.<br>. MA5-15407 detects PYK2 which has a predicted molecular weight of approximately 115.8kDa. This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Type: Primary
Antigen: PYK2
Clonality: Monoclonal
Clone: 5E2D5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAMA515407 Blocked
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SPECIFICATIONS

Antigen symbol PYK2
Antigen name Protein tyrosine kinase 2
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 5E2D5
Host Mouse
Isotype IgG2a
Western Blot Yes
ImmunoChemistry Yes
Antigen synonyms FAK2, PKB, PTK2B, CAKB, PTK, PYK2, FRNK
Gene ID 2185
Format ascites
Immunogen Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.
Form Liquid
Storage Buffer ascites, 0.03% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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