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Anti-APE1 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
In IHC applications, this antibody can be competitively inhibited from recognizing the APE1 antigen in tissues using APE1 protein. This antibody can be used on frozen sections, fixed-paraffin sections and cytospin preps. Suggested positive control: Hela whole cell extract, antigen standard for APEX1 (transient overexpression lysate). The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.

Type: Primary
Antigen: APE1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat, Rabbit, Primates, Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116500 Blocked
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SPECIFICATIONS

Antigen symbol APE1
Antigen name APE1
Reactivity Mouse, Primates, Human, Rabbit, Rat
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
ChIP Yes
Neutralisation Yes
Antigen synonyms APEN, APE1, Apurinic/apyrimidinic (abasic) endonuclease, Apurinic Endonuclase Factor 1, AP endonuclease class I, Apurinic/apy, APEX nuclease, AP lyase
Gene ID 328, 79116, 11792
Concentration 0.5 mg/ml
Immunogen Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris glycine, 0.15M NaCl, 0.05% sodium azide
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping Temperature Ice
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