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Anti-OGG1 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
Suggested positive control: Jurkat whole cell extracts. 8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26.2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.

Type: Primary
Antigen: OGG1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Primates, Mouse, Rat, Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116505 Blocked
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Antigen symbol OGG1
Antigen name 8-Oxoguanine glycosylase
Reactivity Mouse, Rat, Primates, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Flow cytometry Yes
Antigen synonyms MUTM, OGH1, HMMH, HOGG1
Gene ID 81528, 18294, 4968
Concentration 1 mg/ml
Immunogen A peptide derived from the human Ogg1 (within amino acids 1-100).
Purification Antigen affinity chromatography
Form Liquid
Storage buffer PBS, 0.05% sodium azide
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping temperature Ice
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