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Anti-PHD2 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
This antibody does not react with mouse samples. Suggested positive control: antigen standard for EGLN1 (transient overexpression lysate). HIF prolyl hydroxylase 2 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HPH-2, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(402) and Pro(564), and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degredation via the von Hippel-Lindau ubiquitylation complex.

Type: Primary
Antigen: PHD2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Primates, Rat



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Size Pk VWR Catalog Number Quantity
100 µg 100 µl PIEAPA116524 Blocked
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SPECIFICATIONS

Antigen symbol PHD2
Antigen name HIF Prolyl Hydroxylase 2
Reactivity Primates, Rat, Human, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms P4H2, Chromosome 1 Open Reading Frame 12, HIF Prolyl Hydroxylase 2, C1ORF12, HIF-P4H 2, EGL 9 homolog of C. elegans 1, HIFPH2, Prolyl Hy, EGLN 1 EGLN1
Gene ID 54583
Concentration 1 mg/ml
Immunogen A synthetic peptide made to an N-terminal sequence of the human EGL9 homolog 1 (between residues 1-50). [LocusLink ID 54583]
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris citrate, 0.09% sodium azide, pH 7-8
Storage temperature 4° C, do not freeze
Shipping Temperature Ice
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