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Anti-PHD2 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
This antibody does not react with mouse samples. Suggested positive control: antigen standard for EGLN1 (transient overexpression lysate), human glioblastoma cells. HIF prolyl hydroxylase 2 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HPH-2, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(402) and Pro(564), and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

Type: Primary
Antigen: PHD2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Rat, Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116525 Blocked
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SPECIFICATIONS

Antigen symbol PHD2
Antigen name HIF Prolyl Hydroxylase 2
Reactivity Human, Rat
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms HIFPH2, HIF-P4H 2, HIF Prolyl Hydroxylase 2, EGLN 1 EGLN1, Prolyl Hy, Chromosome 1 Open Reading Frame 12, P4H2, EGL 9 homolog of C. elegans 1, C1ORF12
Gene ID 308913, 54583
Concentration 1 mg/ml
Immunogen The epitope recognized by this antibody maps to a region between residues 1 and 50 of human PHD2/HIF Prolyl Hydroxylase 2 using the numbering given in entry NP_0713341 (GeneID 54583)
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris citrate, 0.09% sodium azide, pH 7-8
Storage temperature 4° C, do not freeze
Shipping Temperature Ice
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