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Anti-IREB2 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
This antibody is predicted to work in human based on 100% sequence homology, however preliminary data shows poor reactivity against human protein. This antibody also has 72% sequence homology with rat. Suggested positive control: 3T3 whole cell lysate. Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).

Type: Primary
Antigen: IREB2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116543 Blocked
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SPECIFICATIONS

Antigen symbol IREB2
Antigen name Iron-responsive Element Binding Protein 2
Reactivity Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoFluorescence Yes
Antigen synonyms Iron-responsive element binding protein 2, IRE-BP 2, Iron regulatory protein 2
Gene ID 64602
Concentration 1 mg/ml
Immunogen Synthetic peptide corresponding to the N-terminal residues 1-100 of human IRP2 (UniProt P48200).
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris glycine, 0.15M NaCl, 0.05% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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