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Anti-P4HTM Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
This antibody does not react with mouse samples. Suggested positive control: antigen standard for PH (transient overexpression lysate), HeLa and human glioblastoma cell lysates. Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. Prolyl hydroxylase 4, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It may function as a cellular oxygen sensor and, under normoxic conditions, may targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

Type: Primary
Antigen: P4HTM
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat



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Size Pk VWR Catalog Number Quantity
100 µg 100 µl PIEAPA116560 Blocked
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SPECIFICATIONS

Antigen symbol P4HTM
Antigen name HIF Prolyl Hydroxylase 4
Reactivity Human, Rat
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Antigen synonyms EGLN4, HIF Prolyl Hydroxylase 4
Gene ID 54681
Concentration 1 mg/ml
Immunogen The epitope recognized by this antibody maps to a region between residue 450 and the C-terminus (residue 502) of human PHD4/HIF Prolyl Hydroxylase 4 using the numbering given in entry NP_8088081 (GeneID 54681)
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris citrate, 0.1% sodium azide, pH 7-8
Storage temperature 4° C, do not freeze
Shipping Temperature Ice
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