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Anti-PHD1 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
Suggested positive control: antigen standard for EGLN2 (transient overexpression lysate), Hela whole cell lysate, HeLa and MEF extracts, MEF whole cell lysate. HIF prolyl hydroxylase 1 (HPH-3)is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis.

Type: Primary
Antigen: PHD1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




 

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Size Pk VWR Catalog Number Quantity
100 µg 100 µl PIEAPA116569 Blocked
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SPECIFICATIONS

Antigen symbol PHD1
Antigen name HIF Prolylhydroxylase 1
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Antigen synonyms estrogen-induced tag 6, prolyl hydroxylase domain-containing protein, HIF-P4H 1, P4H1, HIF prolyl hydroxylase 1, EGLN2, EGL nine (C.elegans) homolog 2
Gene ID 112398, 308457, 112406
Concentration 1 mg/ml
Immunogen A region between residue 350 and the C-terminus (residue 407) of human Prolyl Hydroxylase Domain-Containing Protein 1
Purification Antigen affinity chromatography
Form Liquid
Storage buffer tris citrate, 0.1% sodium azide, pH 7-8
Storage temperature 4° C, do not freeze
Shipping temperature Ice
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