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Anti-Carbonic Anhydrase IX Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
Suggested positive control: antigen standard for CA9 (transient overexpression lysate), Renal carcinoma. Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. Because of its functionality, it has become an important diagnostic marker for various cancers, most notably renal cell carcinoma (RCC). There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Type: Primary
Antigen: Carbonic Anhydrase IX
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Plant, Canine, Mouse, Rat



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116592 Blocked
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SPECIFICATIONS

Antigen symbol Carbonic Anhydrase IX
Antigen name Carbonic Anhydrase 9
Reactivity Human, Mouse, Rat, Dog, Plant
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Gel Shift Yes
Flow Cytometry Yes
ChIP Yes
Antigen synonyms Carbonic dehydratase, Membrane antigen MN, pMW1, Renal cell carcinoma associated antigen G250, CA9, P54 / 58N, CAIX, RCC associated protein G250
Gene ID 611933, 313495, 230099, 768
Concentration 1.0 mg/ml
Immunogen A synthetic peptide derived from a C-terminal sequence of the human CA IX.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.025% sodium azide
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping Temperature Ice
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