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Anti-MMP2 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
In Western Blot, bands can be seen at approximately 72kDa (proform) and 62kDa (active form). Antigen retrieval is not required for IHC. Suggested positive control: Injured rat nerve lysate. Loss of negative growth regulation and high invasive potential are neoplastic traits often associated with abnormal expression of matrix matalloproteinases. MMP-2, the signalling mechanism for cells to begin migration, triggers the movement when it splits laminin-5 and exposes and integrin-binding site on this component of epithelial basement membrane. The changed form of laminin was found in tumors and in tissues being altered. The activated form of MMP2, however, is not found in benign tumors. Thus detection of the enzyme is a possible early indicator of tumor activity.

Type: Primary
Antigen: MMP2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Rat, Mouse, Human, Chicken



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116667 Blocked
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SPECIFICATIONS

Antigen symbol MMP2
Antigen name Matrix Metalloproteinase 2
Reactivity Human, Rat, Chicken, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms Collagenase Type 4 alpha, 72 kDa gelatinase, 72kD type IV collagenase, CLG4A, Mat, CLG4, Gelatinase neutrophil, Gelatinase alpha, CLG 4A, Gelatinase A
Gene ID 4313, 386583, 17390, 81686
Concentration 1 mg/ml
Immunogen A synthetic peptide corresponding to residues 475-490 of human MMP-2: MGPLLVATFWPELPEK
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.05% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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