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Anti-TACR1 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
The target sequence has 94% sequence homology with guinea pig. Suggested positive control: antigen standard for TACR1 (transient overexpression lysate), SF9 whole cell membrane extracts. The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma. Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).

Type: Primary
Antigen: TACR1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat, Mouse



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116715 Blocked
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SPECIFICATIONS

Antigen symbol TACR1
Antigen name Substance P Receptor
Reactivity Mouse, Human, Rat
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms NK1 receptor, NK1R, TACR1, Tachykinin receptor 1, Substance P receptor, TAC1R, SPR
Gene ID 21336, 24807, 6869
Concentration 1 mg/ml
Immunogen A peptide derived from the N-terminus of human NK-1 sequence conjugated to KLH.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.02% sodium azide
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping Temperature Ice
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