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Anti-NPC1 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
By Western blot, PA1-16817 detects heterogeneously glycosylated NPC1 protein with prominent bands at ~170 and ~220 kDa. Suggested positive control: human fibroblast cell lysate. Niemann-Pick type C1 (NPC1) is a member of a family of genes encoding membrane-bound proteins containing putative sterol sensing domains. NPC1 protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. NPC1 overexpression increases the rate of trafficking of low density lipoprotein cholesterol to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma membrane. NPC disease is an inherited neurovisceral lipid storage disorder of unesterified cholesterol accumulation in lysosomes. It is characterized by progressive neural and liver degeneration, resulting from inactivating mutations in NPC1, in most cases.

Type: Primary
Antigen: NPC1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Hamster, Human, Primates, Mouse, Porcine, Rat



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116817 Blocked
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Antigen symbol NPC1
Antigen name Niemann-Pick disease type C1
Reactivity Rat, Porcine, Hamster, Mouse, Human, Primates
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Antigen synonyms NPC, FLJ98532
Gene ID 18145, 4864, 397591, 100689424
Concentration 1 mg/ml
Immunogen A synthetic peptide made to the C-terminal region of human NPC1.
Purification Affinity chromatography
Form Liquid
Storage buffer PBS, 0.1% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping temperature Ice
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