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Anti-CD204 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific

Suggested positive control: antigen standard for MSR1 (transient overexpression lysate), mouse liver lysate, mouse liver protein. Macrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a wide variety of negatively charged macromolecules. There are two types of these receptors that differ in the C-terminal region. MSR has a key role in scavenging a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of MSR is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Ab deposition in Alzheimer's disease (AD).The observation that the 4 allele of the apolipoprotein E gene is associated with an increased risk for AD has lead to the investigation of lipoprotein metabolism in the brain of AD patients. The type I MSR has been found to be expressed on microglia and Mato cells, but not astrocytes or neurons. In AD brain, MSR type I is strongly expressed by microglia cells that are associated with senile plaques. Because the senile plaques contain AGEs, which are a source of free radicals that could result in oxidative damage to the brain, MSR may have a role in mediating the endocytosis of AGEs.

Type: Primary
Antigen: CD204
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Primates, Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116825 Blocked
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SPECIFICATIONS

Antigen symbol CD204
Antigen name Macrophage Scavenger Receptor 1
Reactivity Human, Primates
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoFluorescence Yes
Antigen synonyms Scvr, Scara1, MSR, SR-AI, MSR-A, MRS-A, MSR1, SR-AII
Gene ID 4481
Concentration 0.97 mg/ml
Immunogen A synthetic peptide made to an internal portion of the human MSR protein sequence (between residues 300-400). UniProt P21757
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris glycine, 150mM NaCl, 0.05% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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