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Anti-Phospho-Survivin (Thr34) Rabbit Polyclonal Antibody

Supplier: Thermo Scientific

The target sequence has 100% sequence homology with feline and primate, and 94% sequence homology with canine, porcine, and bovine. Regulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a c-terminus RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis.

Type: Primary
Antigen: Phospho-Survivin (Thr34)
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116853 Blocked
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SPECIFICATIONS

Antigen symbol Phospho-Survivin (Thr34)
Antigen name Baculoviral IAP Repeat Containing 5
Reactivity Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoFluorescence Yes
Antigen synonyms EPR 1, SVV, Baculoviral IAP repeat containing 5, API4, BIRC 5, TIAP, IAP4, Apoptosis Inhibitor 4, Apoptosis inhibitor survivin
Gene ID 11799, 332
Modification Phosphorylated: Thr34
Concentration 1 mg/ml
Immunogen A synthetic peptide with a phosphorylated threonine (amino acid 34).
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris citrate, 0.1% sodium azide, pH 7-8
Storage temperature 4° C, do not freeze
Shipping Temperature Ice
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