Anti-PUMA Rabbit Polyclonal Antibody

Supplier: Thermo Fisher Scientific
PIEAPA116861EA 0 EUR
PIEAPA116861
Anti-PUMA Rabbit Polyclonal Antibody
Antibodies
In Western blot, a band at ~16 kDa is seen, representing the beta form of PUMA. Reactivity against the alpha form of PUMA is unknown. Suggested positive control: HL-60 whole cell lysate, antigen standard for BBC3 (transient overexpression lysate). A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Type: Primary
Antigen: PUMA
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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