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Anti-SLC7A11 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
This antibody is not recommended for Immunoprecipitation. Permeablization is recommended prior to performing Flow analysis. Suggested positive control: antigen standard for SLC7A11 (transient overexpression lysate), human stomach protein or stomach tissue lysate. Mammalian amino acid transport systems consist of a large variety of transporters. The amino acid transporter, cystine/glutamic acid transporter xCT, for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc. In brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to enter cells.

Type: Primary
Antigen: SLC7A11
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116893 Blocked
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SPECIFICATIONS

Antigen symbol SLC7A11
Antigen name Solute Carrier Family 7 Member 11
Reactivity Human, Rat, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms Cysteine/glutamate transporter antibody, Calcium channel blocker resistance protein CCBR1 antibody., Amino acid transport system xc-xCT antibody
Gene ID 310392, 23657, 26570
Concentration 1 mg/ml
Immunogen Synthetic peptide between amino acid 1-50 of the human XCT protein.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.02% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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