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Anti-HMGB1 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
This antibody is expected to cross react with porcine, equine and rabbit samples based on 100% sequence homology. Suggested positive control: Hela whole cell extract, antigen standard for HMGB1 (transient overexpression lysate). HMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. These proteins (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. They may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.

Type: Primary
Antigen: HMGB1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Canine, Bovine, Human, Mouse, Rat, Ovine



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116926 Blocked
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SPECIFICATIONS

Antigen symbol HMGB1
Antigen name High-mobility Group Box 1
Reactivity Bovine, Dog, Ovine, Rat, Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms Hmgb1, High mobility group protein 1 antibody, High Mobility Group Box 1 antibody, HMG3 antibody, High mobility group 1 antibody, Amphoterin antibody
Gene ID 101112071, 25459, 3146, 282691, 403170, 15289
Concentration 1 mg/ml
Immunogen Synthetic peptide between to amino acids 100-200 of the human HMGB1 protein.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris glycine, 0.02% sodium azide
Storage temperature 4° C, do not freeze
Shipping Temperature Ice
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