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Anti-IRS1 Rabbit Polyclonal Antibody

Supplier: Thermo Scientific
This antibody does not react with monkey samples. Suggested positive control: Glucose treated pancreatic islets and endogenous protein of pancreatic beta cells (20 ug). IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. It is a transmembrane protein that has both serine-threonine kinase and endoribonuclease acitvities. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER.

Type: Primary
Antigen: IRS1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Rat, Mouse, Human, Rabbit



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116927 Blocked
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SPECIFICATIONS

Antigen symbol IRS1
Antigen name Insulin Receptor Substrate 1
Reactivity Rat, Rabbit, Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Antigen synonyms Ire1-alpha anti, IRE1a antibody, Inositol-requiring protein 1 antibody, Serine/threonine-protein kinase/endoribonuclease IRE1 antibody, IRE1p antibody
Gene ID 2081, 78943, 498013
Modification Phosphorylated: Ser724
Concentration 1 mg/ml
Immunogen Synthetic peptide surrounding the phosphorylated serine 724 of the human IRE1 alpha protein.[Swiss-Prot #O75460]
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.025% sodium azide
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping Temperature Ice
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