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Anti-IRE1A Rabbit Polyclonal Antibody

Supplier: Thermo Scientific

This antibody does not detect monkey IRE1 alpha. Suggested positive control: Pancreatic islets and insulinoma cells. IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. It is a transmembrane protein that has both serine-threonine kinase and endoribonuclease activities. Null mutants are viable, but IRE1 is essential for viablility under stress conditions that cause unfolded proteins to accumulate in the ER.

Type: Primary
Antigen: IRE1A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116928 Blocked
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SPECIFICATIONS

Antigen symbol IRE1A
Antigen name IRE1 alpha
Reactivity Rat, Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoFluorescence Yes
Antigen synonyms IRE1a antibody, Inositol-requiring protein 1 antibody, IRE1p antibody, Serine/threonine-protein kinase/endoribonuclease IRE1 antibody, Ire1-alpha anti
Gene ID 498013, 78943, 2081
Concentration 1 mg/ml
Immunogen Synthetic peptide between amino acids 700-800 of the human IRE1 alpha protein.[Swiss-Prot#075460]
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris glycine, 0.15M NaCl, 0.05% sodium azide
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping Temperature Ice
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