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Anti-HP1 alpha Rabbit Polyclonal Antibody

Supplier: Thermo Scientific

This antibody is expected to cross-react with mouse, Arabidopsis suecica, Rye, and Triticum aestivum based on sequence homology. Suggested positive control: antigen standard for CBX5 (transient overexpression lysate), Hela whole cell extract. Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.

Type: Primary
Antigen: HP1 alpha
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116942 Blocked
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SPECIFICATIONS

Antigen symbol HP1 alpha
Antigen name HP1 alpha
Reactivity Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms Antigen p25 antibody, Chromobox homolog 5 (HP1 alpha homolog Drosophila) antibody, Chromobox protein homolog 5 ant, HP-1 alpha antibody, Cbx5 antibody
Gene ID 23468
Concentration 13 mg/ml
Immunogen Synthetic peptide between amino acids 1-100 of the human HP 1 alpha protein.
Purification Protein G
Form Liquid
Storage Buffer PBS, 0.02% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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