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Anti-HIF3A Rabbit Polyclonal Antibody

Supplier: Thermo Scientific

PA1-16952 is specific for the ~68 kDa HIF-3 alpha protein. Because a band at ~71 kDa is also seen in hypoxic samples, it is important to run a negative control lysate as well. Suggested positive control: Cos7 CoCl2-treated lysate. Hypoxia-inducible factor (HIF) is one of the most important factors in the cellular response to hypoxia, transcriptionally activating genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three subunits, HIF1 alpha, HIF2 alpha, or HIF3 alpha. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation and cell survival. HIF3 alpha protein is one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha 3 subunit lacks the transactivation domain found in factors containing either the alpha 1 or alpha 2 subunits. HIF3 alpha may be a marker for tumor growth and angiogenesis.

Type: Primary
Antigen: HIF3A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse



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Size Pk VWR Catalog Number Quantity
100 µL 100 µl PIEAPA116952 Blocked
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SPECIFICATIONS

Antigen symbol HIF3A
Antigen name Hypoxia inducible Factor 3 alpha Subunit
Reactivity Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Antigen synonyms PASD7, Hypoxia Inducible Factor 3 alpha, IPAS, MOP7, Inhibitory PAS domain protein
Gene ID 64344, 53417
Concentration 24 mg/ml
Immunogen Synthetic peptide between amino acids 250-350 of the human HIF-3 alpha protein. [Swiss-Prot# Q66K72]
Purification Protein G
Form Liquid
Storage Buffer PBS, 0.02% sodium azide
Storage temperature 4° C, do not freeze
Shipping Temperature Ice
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