Anti-Calcineurin A Rabbit Polyclonal Antibody

Supplier: BioVision
BIOV3075-100EA 299 EUR
BIOV3075-100
Anti-Calcineurin A Rabbit Polyclonal Antibody
Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drμgs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.

Recommended Dilutions: Western Blot: 1-4 µg/ml; for Immunoprecipitation: 10-20 µg/ml

Type: Primary
Antigen: Calcineurin A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Hamster, Rabbit, Bovine
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