MLN-4924 ≥98% (by HPLC)

Supplier: BioVision

Synonyms: Pevonedistat((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentylmethyl sulfamate

BIOV2566-1000EA 186 EUR
BIOV2566-1000 BIOV2566-500
MLN-4924 ≥98% (by HPLC)

A potent and selective inhibitor of NEDD8 (Neural precursor cell expressed, developmentally down-regulated 8)-activating enzyme (NAE) (IC50 = 4,7 nM) with potential anticancer activity. NAE activates NEDD8, an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). Supresses the growth of tumor xenografts in mice.

Soluble in DMSO (~10 mg/ml)

Formula: C₂₁H₂₅N₅O₄S
Storage Temperature: Freezer
CAS Number: 905579-51-3

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