Anti-p19ARF Rabbit Polyclonal Antibody (Cy7®)

Supplier: Bioss
BOSSBS-0534R-CY7EA 505 EUR
BOSSBS-0534R-CY7
Anti-p19ARF Rabbit Polyclonal Antibody (Cy7®)
Antibodies
P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: p19ARF
Clonality: Polyclonal
Clone:
Conjugation: Cy7®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat
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