Anti-DNM1 Rabbit Polyclonal Antibody (Cy7®)

Supplier: Bioss
Anti-DNM1 Rabbit Polyclonal Antibody (Cy7®)
Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (2–5). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (2–5). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: DNM1
Clonality: Polyclonal
Conjugation: Cy7®
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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