Anti-JNK1 / JNK2 / JNK3 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Supplier: Bioss
BOSSBS-2592R-A350EA 509 EUR
BOSSBS-2592R-A350
Anti-JNK1 / JNK2 / JNK3 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Antibodies
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: JNK1 / JNK2 / JNK3
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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