Anti-PARK2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Supplier: Bioss
BOSSBS-5552R-A488EA 521 EUR
Anti-PARK2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Parkinson's Disease, the second most common neurodegenerative disease after Alzheimer's Disease, is characterized by the loss of dopaminergic neurons and the presence of Lewy bodies (comprised of alpha synuclein and parkin inclusions). Autosomal Recessive Juvenile Parkinsonism (AR-JP) is a recently described form of Parkinson's Disease that has been linked to a gene that codes for parkin. Parkin, a 52 kDa protein, has a suggested role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: PARK2
Clonality: Polyclonal
Conjugation: Alexa Fluor® 488
Host: Rabbit
Isotype: IgG
Reactivity: Human
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