Anti-TNFSF18 Rat Monoclonal Antibody [clone: MGTL 15]

Supplier: ProSci
PRSI36-009EA 0 EUR
Anti-TNFSF18 Rat Monoclonal Antibody [clone: MGTL 15]
GITRL is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis, . ). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T-cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

ELISA: (direct and indirect: 1:5,000-1:10,000). Flow Cytometry: (1:1,000). Western blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature.). Optimal conditions must be determined individually for each application.

Type: Primary
Antigen: TNFSF18
Clonality: Monoclonal
Clone: MGTL 15
Conjugation: Unconjugated
Host: Rat
Isotype: IgG2a kappa
Reactivity: Mouse
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