Anti-LTBR Rat Monoclonal Antibody [clone: 4H8 WH2]

Supplier: ProSci
PRSI36-101EA 596 EUR
PRSI36-101
Anti-LTBR Rat Monoclonal Antibody [clone: 4H8 WH2]
Antibodies
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.

Type: Primary
Antigen: LTBR
Clonality: Monoclonal
Clone: 4H8 WH2
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse
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