Anti-TNFRSF10A Mouse Monoclonal Antibody [clone: HS101]

Supplier: ProSci
PRSI36-122EA 514 EUR
Anti-TNFRSF10A Mouse Monoclonal Antibody [clone: HS101]
TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

Functional Application: Inhibition (blocks TRAIL-R1 mediated killing if applied in solution).

Type: Primary
Antigen: TNFRSF10A
Clonality: Monoclonal
Clone: HS101
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Human
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