Anti-CD40 Rat Monoclonal Antibody [clone: FGK45]

Supplier: ProSci
PRSI36-148EA 348 EUR
Anti-CD40 Rat Monoclonal Antibody [clone: FGK45]
CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

Functional Application: Activates B and NK cells in vivo and in vitro.

Type: Primary
Antigen: CD40
Clonality: Monoclonal
Clone: FGK45
Conjugation: Unconjugated
Host: Rat
Isotype: IgG2a
Reactivity: Mouse
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