Anti-BTLA Rat Monoclonal Antibody [clone: 6F4]

Supplier: ProSci
PRSI36-160EA 514 EUR
PRSI36-160
Anti-BTLA Rat Monoclonal Antibody [clone: 6F4]
Antibodies
B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

Immunohistochemistry: (frozen sections).

Type: Primary
Antigen: BTLA
Clonality: Monoclonal
Clone: 6F4
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG1
Reactivity: Human
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