Anti-CASP2 Rat Monoclonal Antibody [clone: 10C6]

Supplier: ProSci
PRSI36-178EA 487 EUR
Anti-CASP2 Rat Monoclonal Antibody [clone: 10C6]
Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.

Flow Cytometry: (overexpressed in cell lines) . Immunocytochemistry: (10-20ug/ml; fix in 4% paraformaldehyde, 0.18% Triton-X100 for 10 min. prior to staining) . Immunohistochemistry: (frozen sections). Optimal conditions must be determined individually for each application.

Type: Primary
Antigen: CASP2
Clonality: Monoclonal
Clone: 10C6
Conjugation: Unconjugated
Host: Rat
Isotype: IgG2a kappa
Reactivity: Dog, Human, Monkey, Mouse, Rat
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