Anti-CASP2 Rat Monoclonal Antibody [clone: 11B4]

Supplier: ProSci
PRSI36-179EA 584 EUR
PRSI36-179
Anti-CASP2 Rat Monoclonal Antibody [clone: 11B4]
Antibodies
Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.

Immunoprecipitation: (1-5ug/ml) . Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.

Type: Primary
Antigen: CASP2
Clonality: Monoclonal
Clone: 11B4
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2a kappa
Reactivity: Dog, Human, Monkey, Mouse, Rat
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