Anti-CASP4 Rat Monoclonal Antibody [clone: 4E11]

Supplier: ProSci
PRSI36-183EA 471 EUR
Anti-CASP4 Rat Monoclonal Antibody [clone: 4E11]
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.

ELISA: (recombinant protein). Flow Cytometry: (overexpressed in cell lines). Immunoprecipitation: (1-5ug/ml). Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.

Type: Primary
Antigen: CASP4
Clonality: Monoclonal
Clone: 4E11
Conjugation: Unconjugated
Host: Rat
Isotype: IgG1 kappa
Reactivity: Mouse, Rat
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