The biological functions of RELM beta, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003)). Interestingly the molecular structure of RELM beta is highly homologous to that of the adipose-derived cytokine Resistin and RELM beta. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C.
- Human RELM-beta is a 19.0 kDa disulfide-linked homodimeric protein, consisting of two 89 amino acid residue chains, expressed in the epithelium of the colon and small bowel. Murine RELM-beta (Resistin-like molecule beta/FIZZ2) is an 18 kDa disulfide-linked homodimeric protein, consisting of two 83 amino acid residue chains, expressed in the epithelium of the colon and small bowel.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.