Human recombinant proteinase 3 (from cells)

Supplier: ProSci
PRSI91-542EA 487 EUR
Human recombinant proteinase 3 (from cells)
Proteinase-3 is a neutral serine proteinase that belongs to the peptidase S1 family and Elastase subfamily. It contains one peptidase S1 domain and it is expressed mainly in neutrophil granulocytes. The primary function of Proteinase-3 is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body. It is the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Fusion-Tag: C-6 His tag

This recombinant protein can be used for biological assays. For research use only.
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