Human recombinant Inosine Triphosphatase (from E. coli)

Supplier: ProSci
PRSI91-989EA 658 EUR
Human recombinant Inosine Triphosphatase (from E. coli)
Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyses the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterised by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.

Fusion-Tag: C-6 His tag

This recombinant protein can be used for biological assays. For research use only.
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