1-(Trimethylsilyl)imidazole silylation reagent, for GC derivatisation

Supplier: MACHEREY-NAGEL
Danger

Synonyms: TSIM1-(Trimethylsilyl)-1H-imidazoleTMSIN-(Trimethylsilyl)imidazoleN-(Trimethylsilyl)-1H-imidazole

MANA701310.510EA 350 EUR
MANA701310.510 MANA701310.201 MANA701310.110
1-(Trimethylsilyl)imidazole silylation reagent, for GC derivatisation
1-(Trimethylsilyl)imidazole

TSIM is the strongest hydroxyl silylator; reagent of choice for carbohydrates and most steroids (even highly hindered steroids).


  • Silylation can be applied on many compounds
  • Silylation reagents are easily prepared
  • TSIM selectively derivatizes compounds with different functional groups


The reagent is unique in that it reacts quickly and smooth with hydroxyl (even tert. OH) and carboxyl groups, but not with amines. This characteristic makes TSIM particularly useful in multi-derivatization schemes for compounds with different functional groups, which are to be derivatized differently (e.g., -O-TMS / -N-HFB derivatives of catecholamines). Recommended applications are the derivatizatzion of alcohols, phenols, organic acids, steroids, hormones, glycols, nucleotides and narcotics.

Formula: C₆H₁₂N₂Si
MW: 140,26 g/mol
Boiling Pt: 94–96 °C (760 mm Hg)
Density: 0,961 g/cm³ (d20°/4°)
MDL Number: MFCD00005280
CAS Number: 18156-74-6

Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR