N-Methyl-N-(trimethylsilyl)trifluoroacetamide silylation reagent, for GC derivatisation

Supplier: MACHEREY-NAGEL
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Synonyms: MSTFAN-Methyl-N-(trimethylsilyl)-2,2,2-trifluoroacetamide

MANA701270.110EA 176 EUR
MANA701270.110 MANA701270.201 MANA701270.650 MANA701270.1100 MANA701270.12100 MANA701270.6100 MANA701270.510
N-Methyl-N-(trimethylsilyl)trifluoroacetamide silylation reagent, for GC derivatisation
N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Silylation in GC stands for replacement of active hydrogen atoms by a trimethylsilyl group (TMS derivative).


  • Silylation can be applied on many compounds
  • Silylation reagents are easily prepared
  • MSTFA induces complete reaction with high rates
  • By-product of the reaction (N-methyltrifluoroacetamide) features high volatility and short retention time


MSTFA is the most volatile trimethylsilyl amide. The silylation reagent is a very strong TMS donor which does not cause any noticeable FID contamination even after long-time measuring series.
It is one of the most important derivatisation reagent. It can be used, to silylate hydrochloride salts of amines or amino acids directly. The already good solution characteristics can be improved by adding submolar quantities of protic solvents (e.g., TFA for extremely polar compounds such as hydrochlorides) or pyridine (e.g., for carbohydrates).

Formula: C₆H₁₂F₃NOSi
MW: 199,25 g/mol
Boiling Pt: 70 °C (75 mm Hg)
Density: 1,11 g/cm³ (d20°/4°)
MDL Number: MFCD00000411
CAS Number: 24589-78-4
EINECS: 246-331-6
UN: 2924
ADR: 3,III

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