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During solid phase extraction chromatography, components are separated based on physical and chemical properties. The separation effectiveness is primarily based on choosing the correct SPE sorbents to have maximum retention. Normal phase and reversed phase procedures require SPE sorbents to have a strong polarity so that non-polar compounds will pass through a cartridge or absorb to the surface. Capable of working with automatic equipment for faster results, SPE sorbents improve recovery and precision in separations.